Sutton United have been handed a home tie against Premier League side Arsenal in the fifth round of the FA Cup.
National League leaders Lincoln City, meanwhile, will travel to Burnley after seeing off Championship sides Ipswich and Brighton.
While Arsenal will be overwhelming favourites to progress, Sutton have beaten AFC Wimbledon and Leeds on their artificial pitch at Gander Green Lane.
After drawing 0-0 with Wimbledon, they won 3-1 in the replay at the Cherry Red Records Stadium then defeated a much-changed Leeds side 1-0 at the weekend.
With a capacity of just over 5,000 including less than 1,000 seats, it remains to be seen if the match venue will be changed.
There are no all-Premier League ties in the last 16. If Leicester get through their replay with Derby, they will go to Millwall, who followed up their shock win over Bournemouth earlier in January with a 1-0 success against Watford.
Holders Manchester United and Manchester City will make relatively short away trips to Blackburn and Huddersfield respectively.
Tottenham will also be on the road in another London derby as they take on Championship outfit Fulham, while Oxford – who beat Newcastle 3-0 in the fourth round – travel to Middlesbrough.
In the other tie, Paul Lambert’s Wolves face a Premier League team for the third successive round and, after beating Stoke and Liverpool, they will take on Chelsea.
Ties will be played between February 17 and 20, with Millwall learning whether they will play Leicester or Derby next Wednesday, when they replay at the King Power Stadium.
Full draw:
Burnley v Lincoln City
Fulham v Tottenham
Blackburn v Manchester United
Sutton United v Arsenal
Middlesbrough v Oxford
Huddersfield v Manchester City
Millwall v Derby or Leicester
Wolves v Chelsea
